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兰州大学化学化工学院魏华教授基本情况

日期: 2018-05-08 点击: ...
   

  魏华,男,汉族,1982年2月生,湖北武汉人,中共党员,兰州大学高分子科学与工程研究所所长、博士生导师、教授。2015年5月入选第十一批中组部“千人计划”青年人才项目。

  2000年9月至2004年6月毕业于武汉大学化学与分子科学学院化学基地班专业,获理学学士学位,期间(2003年9月-2004年6月)赴中国科学院长春应用化学研究所高分子物理与化学国家重点实验室交流,完成本科毕业设计(导师:姬相玲研究员)。2004年9月至2009年6月在武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室高分子化学与物理专业获理学博士学位(导师:卓仁禧院士和张先正教授)。博士毕业后于2010年2月至2011年8月在澳大利亚悉尼大学化学与生物分子工程系从事博士后研究(合作导师:Fariba Dehghani教授),同时与悉尼大学化学系聚合物与胶体重点实验室(Key Centre for Polymer and Colloids,KCPC)主任Sebastien Perrier教授开展合作研究。2011年9月至2014年8月在美国西雅图华盛顿大学生物工程系任高级研究员(合作导师:Suzie H. Pun教授)。2014年9月全职回国工作,加盟兰州大学化学化工学院。2015年5月入选第十一批中组部“千人计划”青年人才项目。2017年1月担任兰州大学化学化工学院高分子科学与工程研究所所长、党支部书记。

  研究领域主要集中在高分子化学和生物医用高分子材料,如利用可控聚合设计和制备智能药物、基因载体材料,并通过体外细胞实验和体内动物实验评价其疗效。曾获三星奖学金、宝钢优秀学生特等奖学金、2010年湖北省优秀博士论文、2011年全国优秀博士论文提名奖、悉尼大学博士后奖学金等荣誉和奖励。

  主持科研项目:
  1. 第十一批中组部“千人计划”青年人才项目。
  2. 国家自然科学基金面上项目“新型花形聚合物前药载体的设计、合成及其肿瘤靶向性能研究”,项目号:51473072。
  3. 国家自然科学基金青年基金项目“新型还原敏感性星形阳离子共聚物的设计、合成及其作为非病毒基因载体在体外和体内转染效果的研究”,项目号21504035。

  代表性科研论文:
  (一)以兰州大学为第一单位和通讯作者发表论文
  1. Yunfei Wang, Zhizhen Wu, Zongwei Ma, Xiaoyan Tu, Sijie Zhao, Baoyan Wang, Liwei Ma, Hua Wei*. Promotion of micelle stability using cyclic hydrophilic moiety. Polymer Chemistry 2018. (IF: 5.375, Accepted on 04/16/2018)
  2. Mingqi Wang, Yunfei Wang, Sijie Zhao, Xiaolong Zhang, Hua Wei*. Fabrication of reduction-responsive star-shaped amphiphilic block copolymers with click coupling-generated block junctions toward enhanced therapeutic efficacy. Macromolecular Chemistry and Physics 2018. (IF: 2.5, Accepted on 04/04/2018)
  3. Xiaoyan Tu, Chao Meng, Xiaolong Zhang, Miaoge Jin, Xianshuo Zhang, Xuezhi Zhao, Yunfei Wang, Liwei Ma, Baoyan Wang, Minghu Liu, Hua Wei*. Fabrication of reduction-sensitive amphiphilic cyclic brush copolymer for controlled drug release. Macromolecular Bioscience 2018. (IF: 3.238, Accepted on 04/03/2018)
  4. Huiru Yang, Xuezhi Zhao, Xiaolong Zhang, Liwei Ma, Baoyan Wang, Hua Wei*. Optimization of bioreducible micelles self-assembled from amphiphilic hyperbranched block copolymers for drug delivery. Journal of Polymer Science Part A: Polymer Chemistry 2018. (IF: 2.952, Accepted on 3/30/2018)
  5. Xuezhi Zhao, Kaicheng Deng, Fangjun Liu, Xiaolong Zhang, Huiru Yang, Jinlei Peng, Liwei Ma, Baoyan Wang, Hua Wei*. Fabrication of conjugated amphiphilic triblock copolymer for drug delivery and fluorescence cell imaging. ACS Biomaterials Science and Engineering 2018, 4, 566-575. (IF: 3.234)
  6. Xiaoyan Tu, Chao Meng, Yunfei Wang, Liwei Ma, Baoyan Wang, Jinlin He, Peihong Ni, Xiangling Ji, Mingzhu Liu, Hua Wei*. Fabrication of thermo-sensitive cyclic brush copolymer with enhanced therapeutic efficacy for anticancer drug delivery. Macromolecular Rapid Communications 2018, 1700744. (IF: 4.265, Selected as Back Cover)
  7. Luping Zheng, Yunfei Wang, Xianshuo Zhang, Liwei Ma, Baoyan Wang, Xiangling Ji, Hua Wei*. Fabrication of hyperbranched block-statistical copolymer-based prodrug with dual sensitivities for controlled release. Bioconjugate Chemistry 2018, 29, 190-202. (IF: 4.818)
  8. Cai Zuo, Jinlei Peng, Yong Cong, Xianyin Dai, Xiaolong Zhang, Sijie Zhao, Xianshuo Zhang, Liwei Ma, Baoyan Wang, Hua Wei*. Fabrication of supramolecular star-shaped amphiphilic copolymers for ROS-triggered drug release. Journal of Colloid and Interface Science 2018, 514, 122-131. (IF: 4.233)
  9. Xiaoyan Tu, Chao Meng, Zhe Liu, Lu Sun, Xianshuo Zhang, Ming kui Zhang, Mingrui Sun, Liwei Ma, Mingzhu Liu, Hua Wei*. Synthesis and phase transition of poly(N-isopropylacrylamide)-based thermo-sensitive cyclic brush polymer. Polymers 2017, 9, 301. (IF: 3.364)
  10. Xufeng Zhou, Cong Chang, Yang Zhou, Lu Sun, Hua Xiang, Sijie Zhao, Liwei Ma, Guohua Zheng, Mingzhu Liu, Hua Wei*. A comparison study to investigate the effect of the drug-loading site on its delivey efficacy using double hydrophilic block copolymer-based prodrugs. Journal of Materials Chemistry B 2017, 5, 4443-4454. (IF: 4.543, Selected as Journal of Materials Chemistry B Emerging Investigators 2017 and Back Cover)
  11. Lu Sun L, Yang Zhou, Xufeng Zhou, Qiang Fu, Sijie Zhao, Xiaoyan Tu, Xiaolong Zhang, Liwei Ma, Mingzhu Liu, Hua Wei*. Dual transitions of toothbrush-like double hydrophilic block copolymers. Polymer Chemistry 2017, 8, 500-504. (IF: 5.375)
  12. Sijie Zhao, Huiru Yang, Cai Zuo, Lu Sun, Liwei Ma, Hua Wei*. pH-sensitive drug release of star-shaped micelles with OEG brush corona. RSC Advances 2016, 6, 111217-111225. (IF: 3.108)
  13. Cai Zuo, Xianyin Dai, Sijie Zhao, Xiaoning Liu, Shenglong Ding, Liwei Ma, Mingzhu Liu, Hua Wei*. Fabrication of dual-redox responsive supramolecular copolymers using a reducible β-cyclodextran-ferrocene double-head unit. ACS Macro Letters 2016, 5, 873-878. (IF: 6.185)
  14. Xiaoyan Tu, Minghu Liu, Hua Wei*. Recent progress on cyclic polymers: synthesis, bioproperties, and biomedical applications. Journal of Polymer Science Part A: Polymer Chemistry 2016, 54, 1447-1458. (IF: 2.952, Invited review)
  15. Hua Wei*, Cuiyun Yu. Cyclodextrin-functionalized polymers as drug carriers for cancer therapy. Biomaterials Science 2015, 3, 1050-1060. (IF: 4.210, Invited review)

  (二)加入兰州大学前发表论文
  16. Wang CE, Wei H (共同第一作者), Tan N, Boydston AJ, Pun SH. Sunflower polymers for folate-mediated drug delivery. Biomacromolecules 2016, 17, 69-75. (IF: 5.246)
  17. Wei H, Pun SH. Double-head agents: A powerful tool for synthesizing functional biomaterials. Material Matters 2015, 10, 11-14. (Invited review)
  18. Wei H, Wang CE, Tan N, Boydston AJ, Pun SH. ATRP synthesis of sunflower polymers using cyclic multimacroinitiators. ACS Macro Letters 2015, 4, 938-941. (IF: 6.185)
  19. Wei H, Zhuo RX, Zhang XZ. Design and development of polymeric micelles with cleavable links for intracellular drug delivery. Progress in Polymer Science 2013, 38, 503-535. (IF: 25.766)
  20. Wei H, Chu DSH, Zhao J, Pahang JA, Pun SH. Synthesis and evaluation of cyclic cationic polymers for nucleic acid delivery. ACS Macro Letters 2013, 2, 1047-1050. (IF: 6.185)
  21. Wei H, Volpatti LR, Sellers DL, Maris DO, Andrews IW, Hemphill AS, Chan LW, Chu DSH, Horner PJ, Pun SH. Dual-responsive, stabilized nanoparticles for efficient in vivo plasmid delivery. Angewandte Chemie International Edition 2013, 52, 5377-5381. (IF: 11.994, selected as Very Important Paper (VIP))
  22. Wei H, Pahang JA, Pun SH. Optimization of brush-like cationic copolymers for non-viral gene delivery. Biomacromolecules 2013, 14, 275-284. (IF: 5.246)
  23. Wei H, Schellinger JG, Chu DSH, Pun SH. Neuron-targeted copolymers with sheddable shielding blocks synthesized using a reducible, RAFT-ATRP double-head agent. Journal of the American Chemical Society 2012, 134, 16554-16557. (IF: 13.858)

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