报告题目：Microfluidics and Directed Cell Migration
Cell migration underlies many physiological processes ranging from host defense to wound healing and to cancer metastasis. Diverse environmental factors such as chemical gradients and electric fields can guide the migration and trafficking of various cell types in tissues. Rapid development of microfluidics provides powerful quantitative test bed for cell migration analysis in controlled cellular microenvironments. Toward leveraging microfluidics-based approaches to directed cell migration research, we use microfluidic devices to study chemotactic and electrotactic migration of various cell types. Ongoing research in this direction includes experimental and modeling studies of CCR7-based combinatorial guidance for T cell trafficking in secondary lymphoid tissues, chemotaxis and electrotaxis of lymphocytes, breast cancer cells and adipose-derived stem cells. In addition to fundamental research, we develop integrated and easy-to-use microfluidic cell migration analysis system to explore its practical use for life science research and for clinical applications. An overview of the microfluidic cell migration research program at the University of Manitoba in Canada is provided in this talk.
Dr. Francis Lin
Department of Physics and Astronomy
University of Manitoba
Winnipeg, Manitoba, Canada
Francis Lin obtained his Ph.D. in Physics in 2004 from the University of California, Irvine. He received his postdoc training in immunology at Stanford University School of Medicine from 2005 to 2008. He has been an Assistant Professor in the Department of Physics and Astronomy at the University of Manitoba since 2008 with cross appointment in the Department of Immunology, the Department of Biological Sciences and the Department of Biosystems Engineering. He is directing the microfluidic cell migration research program in the Immunotrafficking Lab with grant support from government and private funding agencies in Canada.